In my experience of building websites - it seems to be Internet Explorer which cannot seem to render a bold version of a font correctly.
Ken - I've just checked your site in FF, Safari and Opera on a mac and they all render the same - nice font definition IMO.
One thing you have to remember is that when you look at your site using a different environment - it is going to be different to you because it is not what you are used to.
I code a different site (or 2) each week and test in different environments and you just have to give and take - no 2 combinations of browser and system will ever produce the same results.
I've always looked at your environmental chemistry site using a mac and it has never ever crossed my mind that it looked "Cartoonish".
If you are really worried about your fonts being bolder then use the font-weight property and the values of 100 - 900 for variations of bold.
To isolate style sheets to work in safari only use this hack
Code:
/*\*/
html>body*.red { color: #FF0000;}
/**/
Hope that helps
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